Evaluating the horizontal ladder assay in a murine model of osteoarthritis

Purpose: The horizontal ladder assay was developed to assess balance, limb co-ordination, and movement deficits. It has been used to study these types of behavioral changes in rodent models of stroke, Parkinson's disease, and spinal cord injury. The purpose of this study was to investigate whether mice develop deficits in the horizontal ladder assay after destabilization of the medial meniscus surgery. In addition, the role of nociceptors and...