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The effect of exercise training on intrahepatic triglyceride and hepatic insulin sensitivity: a systematic review and meta-analysis

Published on Oct 1, 2018in Obesity Reviews 8.19
· DOI :10.1111/obr.12719
Jack A. Sargeant2
Estimated H-index: 2
(NIHR: National Institute for Health Research),
Laura J. Gray60
Estimated H-index: 60
(University of Leicester)
+ 5 AuthorsJames A. King15
Estimated H-index: 15
(NIHR: National Institute for Health Research)
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Abstract
This systematic review and meta-analysis determined the impact of structured exercise training, and the influence of associated weight loss, on intrahepatic triglyceride (IHTG) in individuals with non-alcoholic fatty liver disease (NAFLD). It also examined its effect on hepatic insulin sensitivity in individuals with or at increased risk of NAFLD. Analyses were restricted to studies using magnetic resonance spectroscopy or liver biopsy for the measurement of IHTG and isotope-labelled glucose tracer for assessment of hepatic insulin sensitivity. Pooling data from 17 studies (373 exercising participants), exercise training for one to 24 weeks (mode: 12weeks) elicits an absolute reduction in IHTG of 3.31% (95% CI: -4.41 to -2.22%). Exercise reduces IHTG independent of significant weight change (-2.16 [-2.87 to -1.44]%), but benefits are substantially greater when weight loss occurs (-4.87 [-6.64 to -3.11]%). Furthermore, meta-regression identified a positive association between percentage weight loss and absolute reduction in IHTG (β = 0.99 [0.62 to 1.36], P<0.001). Pooling of six studies (94 participants) suggests that exercise training also improves basal hepatic insulin sensitivity (mean change in hepatic insulin sensitivity index: 0.13 [0.05 to 0.21] mg•m-2•min-1 per μU•mL-1), but available evidence is limited and the impact of exercise on insulin-stimulated hepatic insulin sensitivity remains unclear.
  • References (63)
  • Citations (2)
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References63
Newest
Published on Apr 1, 2018in European Journal of Applied Physiology 3.06
Jack A. Sargeant2
Estimated H-index: 2
(Lboro: Loughborough University),
Stephen Bawden3
Estimated H-index: 3
(University of Nottingham)
+ 9 AuthorsPenny A. Gowland53
Estimated H-index: 53
(University of Nottingham)
Purpose This study examined the feasibility of sprint interval exercise training (SIT) for men with non-alcoholic fatty liver disease (NAFLD) and its effects on intrahepatic triglyceride (IHTG), insulin sensitivity (hepatic and peripheral), visceral (VAT) and subcutaneous adipose tissue (ScAT).
Published on Oct 1, 2017in Nature Reviews Endocrinology 24.65
Max C. Petersen11
Estimated H-index: 11
,
Daniel F. Vatner9
Estimated H-index: 9
,
Gerald I. Shulman142
Estimated H-index: 142
The balance of catabolic and anabolic glucose fluxes in the liver is crucial for glucose homeostasis and is disturbed in diabetes mellitus. In this Review, the authors discuss progress in our understanding of the regulation of hepatic glucose metabolism and highlight potential therapeutic targets for decreasing hepatic glucose production in T2DM, including lipid-induced hepatic insulin resistance, hyperglucagonaemia and excessive adipose lipolysis.
Published on Apr 1, 2017in Hepatology 14.97
Fernando Bril15
Estimated H-index: 15
(UF: University of Florida),
Diana Barb5
Estimated H-index: 5
(UF: University of Florida)
+ 7 AuthorsKenneth Cusi47
Estimated H-index: 47
The cut-off point of intrahepatic triglyceride (IHTG) content to define nonalcoholic fatty liver disease (NAFLD) by proton magnetic resonance spectroscopy (1H-MRS) was established based on the 95th percentile in a group of healthy individuals (i.e., ≥5.56%). Whether this threshold correlates with metabolic and histological changes and whether a further accumulation of IHTG is associated with worsening of these parameters has not been properly assessed in a large cohort of patients. In this cross...
Published on Mar 1, 2017in Nature Reviews Endocrinology 24.65
Lykke Sylow17
Estimated H-index: 17
,
Maximilian Kleinert17
Estimated H-index: 17
+ 1 AuthorsThomas E. Jensen28
Estimated H-index: 28
In this Review, Sylow and colleagues discuss the molecular mechanisms and signalling pathways that regulate glucose uptake from the blood into the muscle during exercise, and the roles of both known and candidate molecules in the process.
Published on Mar 1, 2017in Metabolism-clinical and Experimental 6.51
C. Katsagoni4
Estimated H-index: 4
(RMIT: RMIT University),
Michael Georgoulis7
Estimated H-index: 7
(RMIT: RMIT University)
+ 2 AuthorsMeropi D. Kontogianni19
Estimated H-index: 19
(RMIT: RMIT University)
Abstract Background/Objectives Although lifestyle modifications remain the cornerstone therapy for non-alcoholic fatty liver disease (NAFLD), the optimal lifestyle intervention is still controversial. The aim of this meta-analysis was to evaluate the effect of exercise and/or dietary interventions, type or intensity of exercise and type of diet, on liver function outcomes (liver enzymes, intrahepatic fat and liver histology), as well as on anthropometric and glucose metabolism parameters in NAFL...
Published on Feb 1, 2017in Obesity Reviews 8.19
Edward L. Melanson39
Estimated H-index: 39
(Anschutz Medical Campus)
Summary It is widely assumed that structured exercise causes an additive increase in physical activity energy expenditure (PAEE) and total daily energy expenditure (TDEE). However, the common observation that exercise often leads to a less than expected decrease in body weight, without changes in energy intake, suggests that some compensatory behavioral adaptations occur. A small number of human studies have shown that adoption of structured exercise can lead to decreases in PAEE, which is often...
Published on Jan 1, 2017in Journal of Hepatology 18.95
Ryuki Hashida3
Estimated H-index: 3
(Kurume University),
Takumi Kawaguchi27
Estimated H-index: 27
(Kurume University)
+ 9 AuthorsJacob George85
Estimated H-index: 85
(USYD: University of Sydney)
Background & Aims Exercise is a first-line therapy for patients with non-alcoholic fatty liver disease (NAFLD). We sought to: 1) summarize effective aerobic and resistance exercise protocols for NAFLD; and 2) compare the effects and energy consumption of aerobic and resistance exercises. Methods A literature search was performed using PubMed, Web of Science, and Scopas to January 28, 2016. From a total of 95 articles, 23 studies including 24 aerobic and 7 resistance exercise protocols were selec...
Published on Jan 1, 2017in Clinical Gastroenterology and Hepatology 7.96
David Houghton8
Estimated H-index: 8
(Newcastle University),
Christian Thoma13
Estimated H-index: 13
(Newcastle University)
+ 10 AuthorsChristopher P. Day82
Estimated H-index: 82
(Newcastle University)
Background & Aims Pharmacologic treatments for nonalcoholic steatohepatitis (NASH) are limited. Lifestyle interventions are believed to be effective in reducing features of NASH, although the effect of regular exercise, independent of dietary change, is unclear. We performed a randomized controlled trial to study the effect of exercise on hepatic triglyceride content (HTGC) and biomarkers of fibrosis in patients with NASH. Methods Twenty-four patients (mean age, 52 ± 14 y; body mass index, 33 ± ...
Published on Jan 1, 2017in Digestive Diseases 2.91
Stephen Bawden3
Estimated H-index: 3
,
Robert A. Scott3
Estimated H-index: 3
,
Guruprasad P. Aithal39
Estimated H-index: 39
Background: In the past decades, a number of non-invasive methods have emerged for detecting and estimating liver fibrosis; these include both serum-based panels and imaging-based technology. Some of these methods are now being incorporated in clinical practice. However, the limitations of the current techniques include lack of organ specificity, sampling errors and limited ability to reflect the efficacy of interventions. Key Messages: Novel magnetic resonance (MR)-based techniques provide an o...
Published on Oct 1, 2016in Diabetologia 7.11
Bram Brouwers6
Estimated H-index: 6
(UM: Maastricht University),
Matthijs K. C. Hesselink52
Estimated H-index: 52
(UM: Maastricht University)
+ 1 AuthorsVera B. Schrauwen-Hinderling26
Estimated H-index: 26
(UM: Maastricht University)
Non-alcoholic fatty liver (NAFL) is the most common liver disorder in western society. Various factors may play a role in determining hepatic fat content, such as delivery of lipids to the liver, de novo lipogenesis, hepatic lipid oxidation, secretion of intrahepatic lipids to the circulation or a combination of these. If delivery of lipids to the liver outweighs the sum of hepatic lipid oxidation and secretion, the intrahepatic lipid (IHL) content starts to increase and NAFL may develop. NAFL i...
Cited By2
Newest
Published on Mar 29, 2019
J. Bernadette Moore8
Estimated H-index: 8
Non-alcoholic fatty liver (NAFLD) disease is now a major public health concern with an estimated prevalence of 25-30% of adults in many countries. Strongly associated with obesity and the metabolic syndrome, the pathogenesis of NAFLD is dependent on complex interactions between genetic and environmental factors that are not completely understood. Weight loss through diet and lifestyle modification underpins clinical management; however, the roles of individual dietary nutrients (e.g. saturated a...
Published on Jul 1, 2019in JAMA Internal Medicine 20.77
Dimitrios A Koutoukidis4
Estimated H-index: 4
(NIHR: National Institute for Health Research),
Nerys M. Astbury12
Estimated H-index: 12
(NIHR: National Institute for Health Research)
+ 5 AuthorsPaul Aveyard46
Estimated H-index: 46
(NIHR: National Institute for Health Research)
Importance: Nonalcoholic fatty liver disease (NAFLD) affects about 25% of adults worldwide and is associated with obesity. Weight loss may improve biomarkers of liver disease, but its implications have not been systematically reviewed and quantified. Objective: To estimate the association of weight loss interventions with biomarkers of liver disease in NAFLD. Data Sources: MEDLINE, Embase, PsycINFO, CINAHL, Cochrane, and Web of Science databases along with 3 trial registries were searched from i...
Published on Apr 1, 2019in Journal of Endocrinology 4.38
Rodrigo Martins Pereira3
Estimated H-index: 3
,
Kellen Cristina da Cruz Rodrigues3
Estimated H-index: 3
+ 11 AuthorsAdelino Sanchez Ramos da Silva14
Estimated H-index: 14