Telomerase promoter mutations and copy number alterations in solitary fibrous tumours

Aims Solitary fibrous tumour (SFT) is an infrequently metastasising mesenchymal tumour defined by the NAB2–STAT6 fusion gene. Activating mutations in the telomerase reverse transcriptase ( hTERT ) gene promoter has been reported to associate with adverse patient outcome in SFTs. Methods We analysed the hTERT gene for promoter mutations and copy number alterations in 43 primary extrameningeal SFTs (9 malignant and 34 benign tumours according to...