Enhancement of red blood cell transfusion compatibility using CRISPR‐mediated erythroblast gene editing

Volume: 10, Issue: 6
Published: Jun 1, 2018
Abstract
Regular blood transfusion is the cornerstone of care for patients with red blood cell (RBC) disorders such as thalassaemia or sickle-cell disease. With repeated transfusion, alloimmunisation often occurs due to incompatibility at the level of minor blood group antigens. We use CRISPR-mediated genome editing of an immortalised human erythroblast cell line (BEL-A) to generate multiple enucleation competent cell lines deficient in individual blood...
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Paper Details
Title
Enhancement of red blood cell transfusion compatibility using CRISPR‐mediated erythroblast gene editing
Published Date
Jun 1, 2018
Volume
10
Issue
6
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