Enhancement of red blood cell transfusion compatibility using CRISPR‐mediated erythroblast gene editing
Abstract
Regular blood transfusion is the cornerstone of care for patients with red blood cell (RBC) disorders such as thalassaemia or sickle-cell disease. With repeated transfusion, alloimmunisation often occurs due to incompatibility at the level of minor blood group antigens. We use CRISPR-mediated genome editing of an immortalised human erythroblast cell line (BEL-A) to generate multiple enucleation competent cell lines deficient in individual blood...
Paper Details
Title
Enhancement of red blood cell transfusion compatibility using CRISPR‐mediated erythroblast gene editing
Published Date
Jun 1, 2018
Journal
Volume
10
Issue
6
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