Polygenic risk for schizophrenia and measured domains of cognition in individuals with psychosis and controls

Psychotic disorders including schizophrenia are commonly accompanied by cognitive deficits. Recent studies have reported negative genetic correlations between schizophrenia and indicators of cognitive ability such as general intelligence and processing speed. Here we compare the effect of polygenetic risk for schizophrenia (PRS SCZ ) on measures that differ in their relationships with psychosis onset: a measure of current cognitive abilities...