F180. Spontaneous Eye Blink Rate: A Good Proxy for Dopamine?

Guillaume Sescousse; Romain Ligneul; Ruth J. van Holst; Lieneke Janssen; Femke de Boer; Marcel J.R. Janssen; Anne S. Berry; William J. Jagust; Roshan Cools

doi:https://doi.org/10.1016/j.biopsych.2018.02.794

doi.org/10.1016/j.biopsych.2018.02.794

F180. Spontaneous Eye Blink Rate: A Good Proxy for Dopamine?

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..., Roshan Cools

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Biological Psychiatry10.60

Volume: 83, Issue: 9, Pages: S308 - S309

Published: May 1, 2018

Abstract

Dopamine is central to a number of cognitive functions and brain disorders. Given the cost of neurochemical imaging in humans, behavioral proxy measures of dopamine have gained in popularity in the past decade, such as spontaneous eye blink rate (sEBR). Increased sEBR is commonly associated with increased dopamine function based on pharmacological evidence and patient studies. Yet, this hypothesis has not been validated using in vivo measures of...