Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation

Abstract
SUMMARY Global loss of DNA methylation and CpG island (CGI) hypermethylation are regarded as key epigenomic aberrations in cancer. Global loss manifests itself in partially methylated domains (PMDs) which can extend up to megabases. However, the distribution of PMDs within and between tumor types, and their effects on key functional genomic elements including CGIs are poorly defined. Using whole genome bisulfite sequencing (WGBS) of breast...
Paper Details
Title
Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation
Published Date
Apr 20, 2018
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