Sun-Mediated Mechanical LINC Between Nucleus and Cytoskeleton Regulates βcatenin Nuclear Access
Abstract
βcatenin acts as a primary intracellular signal transducer for mechanical and Wnt signaling pathways to control cell function and fate. Regulation of βcatenin in the cytoplasm has been well studied but βcatenin nuclear trafficking and function remains unclear. In a previous study we showed that, in mesenchymal stem cells (MSC), mechanical blockade of adipogenesis relied on inhibition of βcatenin destruction complex element GSK3β (glycogen...
Paper Details
Title
Sun-Mediated Mechanical LINC Between Nucleus and Cytoskeleton Regulates βcatenin Nuclear Access
Published Date
Jun 6, 2018
Journal
Volume
74
Pages
32 - 40
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Notes
History