Challenge of communicating uncertainty in systematic reviews when applying GRADE ratings

One of the most widely used tools for assessing and communicating scientific uncertainty is Grading of Recommendations Assessment, Development, and Evaluation (GRADE), a system for rating the quality of evidence and grading strength of recommendations in healthcare. More than 100 organisations around the world—WHO included1—are using GRADE or have endorsed it. In GRADE, a quantitative assessment of uncertainty is qualitatively communicated, so...