253. Utilizing a Behavioral Assay of Reward Learning to Predict Clinical Response to a Dopamine Agonist in Individuals With Depression

The efficacy of dopamine (DA) agonists in treating major depressive disorder (MDD) has been tied to their effects on mesolimbic DA and reward function. However, individual responses vary, and an important question is whether DA agonists are most beneficial for depressed individuals with reward-based deficits. This study evaluated whether a behavioral measure of reward learning would predict response to the D3-preferring DA agonist pramipexole...