Astaxanthin prevents the methotrexate-induced reproductive toxicity by targeting oxidative stress in male mice

The future fertility of cancer patients after treatment is a serious concern amongst young cancer patients. Such chemotherapeutic agents as Methotrexate (MTX), a folic acid antagonist can cause long-term or permanent gonadal toxicity in male patients. Oxidative stress is a contributing mechanism to MTX-induced testicular damage. In the past decade, several studies have investigated the use of natural antioxidant agents to prevent the side...