S258. Dorsal, but Not Ventral Striatal Dopamine Mediates the Effect of Gambling Disorder on Compulsivity During Reversal Learning

Gambling disorder is characterized by compulsive gambling. Besides playing an important role in addiction, dopamine – especially in the dorsal striatum – has also been implicated in compulsivity. Recently we found evidence for higher striatal dopamine synthesis capacity in individuals with gambling disorder compared with controls. Here we test the mediating role of dorsal striatum (DS) and ventral striatum (VS) dopamine synthesis capacity in...