Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms
Abstract
Thrombosis is a major cause of morbidity and mortality in Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), clonal disorders of hematopoiesis characterized by activated Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling. Neutrophil extracellular trap (NET) formation, a component of innate immunity, has been linked to thrombosis. We demonstrate that neutrophils from patients with MPNs are...
Paper Details
Title
Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms
Published Date
Apr 11, 2018
Volume
10
Issue
436
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