Association of Cardiomyopathy With MYBPC3 D389V and MYBPC3^Δ25bpIntronic Deletion in South Asian Descendants

The genetic variant MYBPC3Δ25bp occurs in 4% of South Asian descendants, with an estimated 100 million carriers worldwide. MYBPC3 Δ25bp has been linked to cardiomyopathy and heart failure. However, the high prevalence of MYBPC3Δ25bp suggests that other stressors act in concert with MYBPC3Δ25bp.To determine whether there are additional genetic factors that contribute to the cardiomyopathic expression of MYBPC3Δ25bp.South Asian individuals living...