Structures of filaments from Pick’s disease reveal a novel tau protein fold

Nature64.80
Volume: 561, Issue: 7721, Pages: 137 - 140
Published: Aug 29, 2018
Abstract
The ordered assembly of tau protein into abnormal filamentous inclusions underlies many human neurodegenerative diseases1. Tau assemblies seem to spread through specific neural networks in each disease2, with short filaments having the greatest seeding activity3. The abundance of tau inclusions strongly correlates with disease symptoms4. Six tau isoforms are expressed in the normal adult human brain-three isoforms with four microtubule-binding...
Paper Details
Title
Structures of filaments from Pick’s disease reveal a novel tau protein fold
Published Date
Aug 29, 2018
Journal
Volume
561
Issue
7721
Pages
137 - 140
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