Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics
Abstract
The blood coagulation protein fibrinogen is deposited in the brain in a wide range of neurological diseases and traumatic injuries with blood-brain barrier (BBB) disruption. Recent research has uncovered pleiotropic roles for fibrinogen in the activation of CNS inflammation, induction of scar formation in the brain, promotion of cognitive decline and inhibition of repair. Such diverse roles are possible in part because of the unique structure of...
Paper Details
Title
Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics
Published Date
Apr 5, 2018
Journal
Volume
19
Issue
5
Pages
283 - 301
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