The antidiabetic drug metformin blunts NETosis in vitro and reduces circulating NETosis biomarkers in vivo

Published on Jun 1, 2018in Acta Diabetologica2.996
· DOI :10.1007/s00592-018-1129-8
Lisa Menegazzo18
Estimated H-index: 18
(UNIPD: University of Padua),
Valentina Scattolini6
Estimated H-index: 6
(UNIPD: University of Padua)
+ 8 AuthorsGian Paolo Fadini47
Estimated H-index: 47
(UNIPD: University of Padua)
Aims Diabetes is associated with an excess release of neutrophil extracellular traps (NETs) and an enhanced NETosis, a neutrophil cell death programme instrumental to anti-microbial defences, but also involved in tissue damage. We herein investigated whether the antidiabetic drug metformin protects against NETosis.
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