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Penile Traction Therapy and Vacuum Erection Devices in Peyronie's Disease

Published on Apr 1, 2019in Sexual medicine reviews
· DOI :10.1016/j.sxmr.2018.02.005
R. Avant2
Estimated H-index: 2
(Mayo Clinic),
Matthew J. Ziegelmann9
Estimated H-index: 9
(Mayo Clinic)
+ 3 AuthorsLandon Trost14
Estimated H-index: 14
(Mayo Clinic)
Cite
Abstract
Abstract Introduction Peyronie's disease (PD) has historically been managed by at least 1 treatment, including oral supplements or medications, intralesional injections, or surgery. Adjunctive mechanical therapies also have been described, including penile traction therapy (PTT) and vacuum erection devices (VEDs), although relatively limited data are available on their use with PD. Aim To review and summarize the published literature on the role and efficacy of PTT and VED in men with PD. Methods A PubMed search was performed of all publications on PTT and VED in men with PD from inception through September 2017. Main Outcome Measures Changes in penile curvature, length, girth, erectile function, and adverse events with PTT or VED. Results PTT and VED exhibit mechanisms to improve aspects of PD, although clinical outcomes data are limited. Based on current data, PTT likely has a potential role as a primary lengthening therapy (modest improvements), in curvature correction (acute phase; unclear role in chronic phase), before penile prosthesis insertion, and after surgical correction of PD. The role of PTT as a combination therapy during collagenase Clostridium histolyticum injections is unclear. Fewer and lower level-of-evidence studies are available on VEDs and suggest potential roles in curvature correction, before penile prosthesis placement, or after PD surgery. Guideline statements from the American Urological Association and International Consultation on Sexual Medicine also support the potential role of PTT and VED in managing PD. Conclusions PTT and VED represent viable therapeutic options for managing PD, with more data currently available on PTT. Because all PTT studies used a similar style of traction device, it is unclear whether results reflect outcomes of these particular devices or traction more broadly. Further studies are required to better delineate the benefits of PTT and VED, particularly in relation to other established treatments. Avant RA, Ziegelman M, Nehra A, et al. Penile Traction Therapy and Vacuum Erection Devices in Peyronie's Disease. Sex Med Rev 2019;7:338–348.
  • References (54)
  • Citations (4)
Cite
References54
Newest
Published on Nov 1, 2017in BJUI4.52
Amr Abdel Raheem11
Estimated H-index: 11
(Cairo University),
M. Capece3
Estimated H-index: 3
(UCLH: University College Hospital)
+ 7 AuthorsDavid Ralph44
Estimated H-index: 44
(UCLH: University College Hospital)
Objectives To evaluate the efficacy and safety of collagenase clostridium histolyticum (CCH) (Xiapex®, Xiaflex®) in the treatment of Peyronie's disease (PD) using a new modified treatment protocol which aims at reducing the number of injections needed and reducing patient visits, thus reducing the cost and duration of treatment. Patients and Methods A prospective study of 53 patients with PD who had treatment with CCH at a single center using a new modified protocol. The angle of curvature asses...
Published on Oct 1, 2017in The Journal of Sexual Medicine3.65
Haocheng Lin10
Estimated H-index: 10
(PKU: Peking University),
Chunhui Liu2
Estimated H-index: 2
(SEU: Southeast University),
Run Wang21
Estimated H-index: 21
(University of Texas at Austin)
Abstract Background Penile traction therapy with the use of a traction device (TD) or vacuum erectile device (VED) has been studied as local modalities for Peyronie’s disease (PD). Aim To identify changes of penile curvature, erectile function, and possible cellular and molecular mechanisms between the TD and VED in a rat model of PD. Methods Peyronie’s plaque was induced in 30 adult male rats. Then, rats were randomly divided into control (PD without treatment), VED, and TD groups. In the VED g...
Published on Aug 1, 2017in BJUI4.52
Yoshifumi Kadono12
Estimated H-index: 12
(Kanazawa University),
Kazuaki Machioka5
Estimated H-index: 5
(Kanazawa University)
+ 9 AuthorsHiroyuki Konaka16
Estimated H-index: 16
(Kanazawa University)
Objective To measure changes in penile length (PL) over time before and after radical prostatectomy (RP), and to investigate the underlying mechanisms for these changes. Patients and Methods The stretched PL (SPL) of 102 patients was measured before, 10 days after, and at 1, 3, 6, 9, 12, 18 and 24 months after RP. The perpendicular distance from the distal end of the membranous urethra to the midline of the pelvic outlet was measured on mid-sagittal magnetic resonance imaging (MRI) slice at thre...
Published on Jun 1, 2017in Urology1.86
Matthew J. Ziegelmann9
Estimated H-index: 9
(Mayo Clinic),
Boyd R. Viers12
Estimated H-index: 12
(Mayo Clinic)
+ 3 AuthorsLandon Trost14
Estimated H-index: 14
(Mayo Clinic)
Objective To evaluate the outcomes in men undergoing collagenase Clostridium histolyticum (CCH) with concurrent penile traction therapy (PTT) for the treatment of Peyronie disease (PD). Materials and Methods We identified patients treated with CCH between March 2014 and July 2016. Patients were recommended to perform modeling and PTT between injection series. A final curve assessment was performed after patients completed CCH. A prospective database was maintained, including patient-reported fre...
Published on Apr 1, 2017in Sexual medicine reviews
Faysal A. Yafi14
Estimated H-index: 14
(Tulane University),
Georgios Hatzichristodoulou10
Estimated H-index: 10
(TUM: Technische Universität München)
+ 1 AuthorsWayne J.G. Hellstrom61
Estimated H-index: 61
(Tulane University)
Abstract Introduction Peyronie's disease (PD) is a wound-healing disorder of the tunica albuginea often associated with penile deformity. Less commonly, patients with PD might display atypical presentations such as ventral curvature, hourglass deformity, significantly shortened penis, and/or multiplanar curvature. Aim To review the available literature on the prevalence of and management options for atypical PD. Methods A literature review was performed through PubMed from 1982 through 2016 rega...
Published on Jan 1, 2017in Journal of Andrology3.11
Onder Canguven5
Estimated H-index: 5
(Hamad Medical Corporation),
Raidh A. Talib3
Estimated H-index: 3
(Hamad Medical Corporation)
+ 3 AuthorsAbdulla Al-Ansari12
Estimated H-index: 12
(Hamad Medical Corporation)
Summary Patient concerns about penile length after penile prosthesis (PP) implantation for erectile dysfunction (ED) have significant impact on patients and their partners. In addition, corporal fibrosis is associated with difficult PP implantation. The preoperative use of vacuum erectile devices (VED) is an uncommon physical treatment for such concerns. Therefore, the current randomized controlled study assessed two outcomes: whether pre-operative VED use for a month before surgery would signif...
Published on Nov 1, 2016in The Journal of Sexual Medicine3.65
Landon Trost14
Estimated H-index: 14
(Mayo Clinic),
Ricardo Munarriz28
Estimated H-index: 28
(BU: Boston University)
+ 2 AuthorsLaurence A. Levine50
Estimated H-index: 50
(Rush University Medical Center)
Abstract Introduction The field of sexual medicine is continuously advancing, with novel outcomes reported on a regular basis. Given the rapid evolution, updated guidelines are essential to inform practicing clinicians on best practices. Aim To summarize the current literature and provide clinical guidelines on penile traction therapy, vacuum erection devices, and penile revascularization. Methods A consensus panel was held with leading sexual medicine experts during the 2015 International Consu...
Published on Apr 1, 2016in The Journal of Urology5.65
Matthew J. Ziegelmann9
Estimated H-index: 9
(Mayo Clinic),
Boyd R. Viers12
Estimated H-index: 12
(Mayo Clinic)
+ 3 AuthorsLandon Trost14
Estimated H-index: 14
(Mayo Clinic)
Purpose: Collagenase clostridium histolyticum is approved for the treatment of Peyronie’s disease. To date, no post-release study to our knowledge has evaluated patient perceived outcomes and satisfaction. Therefore, we evaluated patient perceived experience with collagenase clostridium histolyticum injection for Peyronie’s disease in a clinical practice.Materials and Methods: From March 2014 to July 2015, 69 patients underwent 1 to 4 series of collagenase clostridium histolyticum injections for...
Published on Sep 1, 2015in The Journal of Urology5.65
Faysal A. Yafi14
Estimated H-index: 14
(Tulane University),
Michael R. Pinsky79
Estimated H-index: 79
(Tulane University)
+ 5 AuthorsWayne J.G. Hellstrom61
Estimated H-index: 61
(Tulane University)
Purpose: The concomitant use of penile traction therapy with interferon α-2b has been previously described. We present an update on our clinical experience to assess the benefit and duration of daily traction.Materials and Methods: A retrospective review of patients who underwent interferon α-2b therapy between 2001 and 2012 was performed. Charts were reviewed and data collected regarding various patient demographics, vascular parameters, objective length and curvature measurements, and use of p...
Published on Jun 1, 2015in The Journal of Sexual Medicine3.65
Martin K. Gelbard16
Estimated H-index: 16
,
Larisa Chagan1
Estimated H-index: 1
,
James P. Tursi11
Estimated H-index: 11
Abstract Introduction The conception of collagenase Clostridium histolyticum (CCH) as treatment for Peyronie's disease (PD) was a vital first step in providing a nonsurgical, minimally invasive FDA-approved treatment for men with PD. Aim To review the origins, clinical research history, and ultimately FDA approval of collagenase as PD treatment. Methods A PubMed search using (Peyronie's or Peyronie) AND collagenase, and limited to clinical research studies, returned nine papers that were examine...
Cited By4
Newest
Published on Jan 1, 2019in Therapeutic Advances in Urology
Karen Randhawa (Western General Hospital), Cj Shukla (Western General Hospital)
Peyronies disease (PD) is estimated to affect approximately 3–9% of men worldwide and maybe associated with pain, erectile dysfunction and penile deformity including shortening. The condition has significant debilitating effects on quality of life, self-esteem and psychological wellbeing in addition to sexual function. Surgical results add further to this by patients having dissatisfaction with various aspects of outcomes. Non-surgical management may allow patients to avoid the morbidities assoc...
Abstract Introduction Peyronie's disease (PD) is the fibrous scar tissue inside the penis that causes curved and painful erections. PD is associated with, diabetes, hypertension, dyslipidemia and low testosterone. PD causes erectile dysfunction (ED). The aim of this study was to evaluate the prevalence of PD in type 2 diabetic (T2DM) patients in Yazd. Methods This cross-sectional study was conducted on 317 patients with T2DM referred to the Diabetes Research Center of Yazd. Inclusion Criteria we...
Published on Jan 1, 2019in The World Journal of Men's Health
A. Cocci6
Estimated H-index: 6
(UniFI: University of Florence),
Fabrizio Di Maida2
Estimated H-index: 2
(UniFI: University of Florence)
+ 9 AuthorsAndrea Mari55
Estimated H-index: 55
(UniFI: University of Florence)
Published on Oct 1, 2018in The Journal of Sexual Medicine3.65
A. Cocci6
Estimated H-index: 6
(UniFI: University of Florence),
G. Cito4
Estimated H-index: 4
(UniFI: University of Florence)
+ 19 AuthorsMarco Capece3
Estimated H-index: 3
(University of Naples Federico II)
Abstract Introduction The effectiveness of phosphodiesterase type 5 (PDE5) inhibitors over the conservative management of Peyronie’s disease (PD) has been widely questioned. Aim To determine the role of sildenafil 25 mg film formulation twice a day (S25 b.i.d.) in the improvement of curvature after treatment of collagenase of Clostridium hystoliticum (CCH) in penile curvature owing to PD. Methods From April 2017 to April 2018, 161 consecutive patients were treated with S25 b.i.d. + CCH or CCH al...
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