Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients
Volume: 59, Issue: 5, Pages: 1910 - 1910
Published: Apr 5, 2018
Abstract
To study longitudinal changes of anti-drug antibody (ADA) titers to recombinant adeno-associated virus serotype 8 (rAAV8) capsid epitopes in nonhuman primates (NHP) and patients.Three groups of six NHP each received subretinal injections (high dose: 1 × 1012 vector genomes [vg], low dose: 1 × 1011 vg, or vehicle only). Four additional animals received intravitreal injections of the high dose (1 × 1012 vg). Three patients received 1 × 1010 vg as...
Paper Details
Title
Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients
Published Date
Apr 5, 2018
Volume
59
Issue
5
Pages
1910 - 1910
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