Oligonucleotide conjugated multi-functional adeno-associated viruses
Abstract
Recombinant adeno-associated viruses (AAVs) are among the most commonly used vehicles for in vivo gene delivery. However, their tropism is limited, and additionally their efficacy can be negatively affected by prevalence of neutralizing antibodies in sera. Methodologies to systematically engineer AAV capsid properties would thus be of great relevance. In this regard, we develop here multi-functional AAVs by engineering precision tethering of...
Paper Details
Title
Oligonucleotide conjugated multi-functional adeno-associated viruses
Published Date
Feb 26, 2018
Journal
Volume
8
Issue
1
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