C.elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death
Abstract
Lysosomes are degradation and signaling centers within the cell, and their dysfunction impairs a wide variety of cellular processes. To understand the cellular effect of lysosome damage, we screened natural small-molecule compounds that induce lysosomal abnormality using Caenorhabditis elegans (C. elegans) as a model system. A group of vobasinyl-ibogan type bisindole alkaloids (ervachinines A-D) were identified that caused lysosome enlargement...
Paper Details
Title
C.elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death
Published Date
Apr 2, 2018
Journal
Volume
9
Issue
12
Pages
1013 - 1026
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