RNA-Targeted Therapeutics
Abstract
RNA-targeted therapies represent a platform for drug discovery involving chemically modified oligonucleotides, a wide range of cellular RNAs, and a novel target-binding motif, Watson-Crick base pairing. Numerous hurdles considered by many to be impassable have been overcome. Today, four RNA-targeted therapies are approved for commercial use for indications as diverse as Spinal Muscular Atrophy (SMA) and reduction of low-density lipoprotein...
Paper Details
Title
RNA-Targeted Therapeutics
Published Date
Apr 1, 2018
Journal
Volume
27
Issue
4
Pages
714 - 739
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Notes
History