ATP Synthase Diseases of Mitochondrial Genetic Origin
Abstract
Devastating human neuromuscular disorders have been associated to defects in the ATP synthase. This enzyme is found in the inner mitochondrial membrane and catalyzes the last step in oxidative phosphorylation, which provides aerobic eukaryotes with ATP. With the advent of structures of complete ATP synthases, and the availability of genetically approachable systems such as the yeast Saccharomyces cerevisiae, we can begin to understand these...
Paper Details
Title
ATP Synthase Diseases of Mitochondrial Genetic Origin
Published Date
Apr 4, 2018
Journal
Volume
9
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History