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Hepatitis C viral load in HCV-monoinfected and HCV/HIV-1-, HCV/HTLV-1/-2-, and HCV/HIV/HTLV-1/-2-co-infected patients from São Paulo, Brazil

Published on Mar 1, 2018in Brazilian Journal of Infectious Diseases2.223
· DOI :10.1016/j.bjid.2018.03.002
Fabiana Aparecida Alves1
Estimated H-index: 1
,
Karoline Rodrigues Campos2
Estimated H-index: 2
+ 2 AuthorsAdele Caterino-de-Araujo8
Estimated H-index: 8
Abstract
Co-infections of hepatitis C virus (HCV) and either human immunodeficiency virus type 1 (HIV-1), human T-cell lymphotropic virus type 1 (HTLV-1) or type 2 (HTLV-2) have been described as having an impact on HCV viremia and subsequent disease progression. HCV load in serum samples from 622 patients (343 males, 279 females; median age 50.8 years) from Sao Paulo/southeast Brazil was analyzed using the Abbott Real Time HCV assay (Abbott Molecular Inc., IL, USA). Samples were obtained from HCV-monoinfected ( n  = 548), HCV/HIV-1- ( n  = 41), HCV/HTLV-1- ( n  = 16), HCV/HTLV-2- ( n  = 8), HCV/HIV/HTLV-1- ( n  = 4), and HCV/HIV/HTLV-2-co-infected ( n  = 5) patients, and results were compared among the groups and according to sex. The median HCV load in HCV-monoinfected patients was 5.23 log 10 IU/mL and 0.31 log 10 higher in men than in women. Increases in viral load of 0.51 log 10 , 0.54 log 10 , and 1.43 log 10 IU/mL were detected in HCV/HIV-1-, HCV/HTLV-1- and HCV/HIV/HTLV-1-co-infected individuals, respectively, compared with HCV-monoinfected counterparts. In contrast, compared to HCV/HIV co-infected patients, HCV/HTLV-2-co-infected patients had an HCV load of 5.0 log 10 IU/mL, whereas HCV/HIV/HTLV-2-co-infected patients had a median load 0.37 log 10 IU/mL lower. Significant differences in HCV loads were detected, with males and HCV/HIV-1- and HCV/HIV/HTLV-1-co-infected patients presenting the highest values. Conversely, females and HCV/HTLV-2-co-infected patients exhibited lower HCV loads. Overall, HCV viremia is increased in HIV and/or HTLV-1-co-infection and decreased in HTLV-2 co-infection.
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  • Citations (1)
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References24
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#2Mandana Namayandeh (Shiraz University of Medical Sciences)H-Index: 5
Last. Mazyar Ziyaeyan (Shiraz University of Medical Sciences)H-Index: 13
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Background Because of shared modes of transmission, patients with hepatitis C virus (HCV) infection are often co-infected with other types of hepatitis viruses and/or HIV. We studied HCV viral load and its genotype patterns among HCV mono- and HCV/HIV co-infected Illicit Drug Users in Fars province-Iran.
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#1Otávio de Melo Espíndola (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 5
#2Alexandre Vizzoni (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 5
Last. Ana Claudia C. Leite (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 3
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Human T-cell lymphotropic virus type 1 (HTLV-1) infection is associated with neurological abnormalities, such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and peripheral neuropathy (PN). Hepatitis C virus (HCV) infection is the leading cause of chronic liver disease worldwide, and causes PN in approximately 9% of patients. Because the interplay between these potentially neuropathogenic viruses in the same individual is still poorly understood, the clinical and laborator...
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Edgard Marcelino de Carvalho Filho. Fundacao Oswaldo Cruz. Instituto Goncalo Moniz. Salvador, BA, Brasil. "Documento produzido em parceria ou por autor vinculado a Fiocruz, mas nao consta a informacao no documento".
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a b s t r a c t Background: While 20–40% of patients with hepatitis C virus (HCV) monoinfection will spontaneously clear the virus, less is known regarding clearance with coinfections. HCV, human immunodeficiency virus (HIV), and human T-cell lymphotrophic virus 1 and 2 (HTLV-1/2) coinfection occurs due to shared routes of transmission and is prevalent in Brazil. Objectives: To compare the proportion of patients who have spontaneously cleared HCV in patients with HCV monoinfection to patients co...
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BACKGROUND: The human retroviruses HIV-1 and HTLV-1 share the routes of infection with hepatitis viruses B and C. Co-infection by these agents are a common event, but we have scarce knowledge on co-infection by two or more of these agents. OBJECTIVE: To evaluate the characteristics and risk factors for co-infections by HBV and HCV in patients infected by HIV-1 or/and HTLV-1, in Salvador, Brazil. METHODS: In a case-control study we evaluated patients followed in the AIDS and HTLV clinics of Feder...
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Background Hepatitis C chronic liver disease is a major cause of liver transplant in developed countries. This article reports the first nationwide population-based survey conducted to estimate the seroprevalence of HCV antibodies and associated risk factors in the urban population of Brazil.
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Abstract HTLV-2/HIV-1-coinfected patients and HIV-infected patients with natural HIV-1 control show an immune capacity that allows some control of viral infections. These two groups of patients have showed an immune capacity that allows them to have some control over viral infections, very strong control of HIV-1 replication in the case of HIV-1 controllers. The purpose of this retrospective cross-sectional study was to compare viral and immunologic parameters between three cohorts of Caucasian ...
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