Cerebrospinal fluid β-amyloid42 and neurofilament light relate to white matter hyperintensities
Abstract
White matter hyperintensities (WMHs) are associated with poorer brain health, but their pathophysiological substrates remain elusive. To better understand the mechanistic underpinnings of WMHs among older adults, this study examined in vivo cerebrospinal fluid biomarkers of β-amyloid42 deposition (Aβ42), hyperphosphorylated tau pathology, neurodegeneration (total tau), and axonal injury (neurofilament light [NFL]) in relation to log-transformed...
Paper Details
Title
Cerebrospinal fluid β-amyloid42 and neurofilament light relate to white matter hyperintensities
Published Date
Aug 1, 2018
Journal
Volume
68
Pages
18 - 25
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