Retrospective harm benefit analysis of pre-clinical animal research for six treatment interventions

Background The harm benefit analysis (HBA) is the cornerstone of animal research regulation and is considered to be a key ethical safeguard for animals. The HBA involves weighing the anticipated benefits of animal research against its predicted harms to animals but there are doubts about how objective and accountable this process is. Objectives i. To explore the harms to animals involved in pre-clinical animal studies and to assess these against...