A PRDX1-p38α heterodimer amplifies MET-driven invasion ofIDH-wildtype andIDH-mutant gliomas

Volume: 143, Issue: 5, Pages: 1176 - 1187
Published: Apr 16, 2018
Abstract
The Peroxiredoxin 1 (PRDX1) gene maps to chromosome arm 1p and is hemizygously deleted and epigenetically silenced in isocitrate dehydrogenase 1 or 2 (IDH)-mutant and 1p/19q-codeleted oligodendroglial tumors. In contrast, IDH-wildtype astrocytic gliomas including glioblastomas mostly lack epigenetic silencing and express PRDX1 protein. In our study, we investigated how PRDX1 contributes to the infiltrative growth of IDH-wildtype gliomas....
Paper Details
Title
A PRDX1-p38α heterodimer amplifies MET-driven invasion ofIDH-wildtype andIDH-mutant gliomas
Published Date
Apr 16, 2018
Volume
143
Issue
5
Pages
1176 - 1187
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