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Allogeneic iPSC-Derived RPE Cell Graft Failure Following Transplantation Into the Subretinal Space in Nonhuman Primates

Published on Mar 8, 2018in Investigative Ophthalmology & Visual Science 3.81
· DOI :10.1167/iovs.17-22467
Trevor J. McGill40
Estimated H-index: 40
(Oregon National Primate Research Center),
Jonathan Stoddard3
Estimated H-index: 3
(Oregon National Primate Research Center)
+ 6 AuthorsMartha Neuringer37
Estimated H-index: 37
(Oregon National Primate Research Center)
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  • References (50)
  • Citations (2)
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References50
Newest
Published on Sep 1, 2017in Ophthalmic Surgery and Lasers
Steven S Saraf1
Estimated H-index: 1
(UM: University of Miami),
Matthew A Cunningham1
Estimated H-index: 1
+ 4 AuthorsThomas A. Albini26
Estimated H-index: 26
A 77-year-old woman with exudative macular degeneration underwent bilateral intravitreal injections of "stem cells" at a clinic in Georgia. One month and 3 months after injection, she developed retinal detachments in the left and right eyes, respectively. Increased awareness within the medical community of such poor outcomes is critical so that clinics offering untested practices that have been shown to be potentially harmful to patients can be identified and brought under U.S. Food and Drug Adm...
Published on May 1, 2017in Translational Vision Science & Technology 2.40
Trevor J. McGill40
Estimated H-index: 40
(Oregon National Primate Research Center),
Osnat Bohana-Kashtan1
Estimated H-index: 1
+ 9 AuthorsBenjamin Reubinoff39
Estimated H-index: 39
(HUJI: Hebrew University of Jerusalem)
Published on Mar 15, 2017in The New England Journal of Medicine 70.67
Ajay E. Kuriyan12
Estimated H-index: 12
,
Thomas A. Albini26
Estimated H-index: 26
+ 7 AuthorsJeffrey L. Goldberg30
Estimated H-index: 30
(Stanford University)
Adipose tissue–derived “stem cells” have been increasingly used by “stem-cell clinics” in the United States and elsewhere to treat a variety of disorders. We evaluated three patients in whom severe bilateral visual loss developed after they received intravitreal injections of autologous adipose tissue–derived “stem cells” at one such clinic in the United States. In these three patients, the last documented visual acuity on the Snellen eye chart before the injection ranged from 20/30 to 20/200. T...
Published on Nov 1, 2016in Stem Cells Translational Medicine 5.96
Kiyoharu Miyagishima8
Estimated H-index: 8
(NIH: National Institutes of Health),
Qin Wan5
Estimated H-index: 5
(NIH: National Institutes of Health)
+ 14 AuthorsTimothy A. Blenkinsop12
Estimated H-index: 12
(ISMMS: Icahn School of Medicine at Mount Sinai)
Acknowledgements Induced pluripotent stem cells (iPSCs) can be efficiently differentiated into retinal pigment epithelium (RPE), offering the possibility of autologous cell replacement therapy for retinal degeneration stemming from RPE loss. The generation and maintenance of epithelial apical-basolateral polarity is fundamental for iPSC-derived RPE (iPSC-RPE) to recapitulate native RPE structure and function. Presently, no criteria have been established to determine clonal or donor based heterog...
Published on Oct 2, 2016in Expert Review of Molecular Diagnostics 3.10
Michael Nasr1
Estimated H-index: 1
(UCSF: University of California, San Francisco),
Tara K. Sigdel25
Estimated H-index: 25
(UCSF: University of California, San Francisco),
Minnie M. Sarwal47
Estimated H-index: 47
(UCSF: University of California, San Francisco)
ABSTRACTIntroduction: Identification of allograft injury, including acute clinical and subclinical injury, is vital in increasing the longevity of the transplanted organ. Acute rejection, which occurs as a result of a variety of immune and non-immune factors including the infiltration of immune cells and antibodies to the donor specific epitopes, poses a significant risk to the organ. Recent years have marked an increase in the discovery of new genomic, transcriptomic, and proteomic biomarkers i...
Published on Oct 1, 2016in Stem cell reports 5.50
Sunao Sugita36
Estimated H-index: 36
,
Yuko Iwasaki4
Estimated H-index: 4
(Tokyo Medical and Dental University)
+ 4 AuthorsMasayo Takahashi43
Estimated H-index: 43
Allografts of retinal pigment epithelial (RPE) cells have been considered for the treatment of ocular diseases. We recently started the transplantation of induced pluripotent stem cell (iPSC)-derived RPE cells for patients with age-related macular degeneration (autogenic grafts). However, there are at least two problems with this approach: (1) high cost, and (2) uselessness for acute patients. To resolve these issues, we established RPE cells from induced iPSCs in HLA homozygote donors. In vitro...
Published on Apr 26, 2016in Investigative Ophthalmology & Visual Science 3.81
Steven D. Schwartz40
Estimated H-index: 40
(UCLA: University of California, Los Angeles),
Gavin Tan2
Estimated H-index: 2
(UCLA: University of California, Los Angeles)
+ 1 AuthorsAaron Nagiel10
Estimated H-index: 10
(UCLA: University of California, Los Angeles)
Published on Mar 22, 2016in Investigative Ophthalmology & Visual Science 3.81
Trevor J. McGill40
Estimated H-index: 40
(Oregon National Primate Research Center),
Lauren Renner6
Estimated H-index: 6
(Oregon National Primate Research Center),
Martha Neuringer37
Estimated H-index: 37
(Oregon National Primate Research Center)
We quantified fundus autofluorescence (FAF) in the nonhuman primate retina as a function of age and diets lacking lutein and zeaxanthin (L/Z) and omega-3 fatty acids.Quantitative FAF was measured in a cross-sectional study of rhesus macaques fed a standard diet across the lifespan, and in aged rhesus macaques fed lifelong diets lacking L/Z and providing either adequate or deficient levels of omega-3 fatty acids. Macular FAF images were segmented into multiple regions of interest, and mean gray v...
Hiroshi Shirai2
Estimated H-index: 2
(Nagoya University),
Michiko Mandai35
Estimated H-index: 35
+ 10 AuthorsHiroko Terasaki39
Estimated H-index: 39
(Nagoya University)
Retinal transplantation therapy for retinitis pigmentosa is increasingly of interest due to accumulating evidence of transplantation efficacy from animal studies and development of techniques for the differentiation of human embryonic stem cells (hESCs) and induced pluripotent stem cells into retinal tissues or cells. In this study, we aimed to assess the potential clinical utility of hESC-derived retinal tissues (hESC-retina) using newly developed primate models of retinal degeneration to obtai...
Cited By2
Newest
Published on Aug 1, 2019in Regulatory Toxicology and Pharmacology 3.00
Sung-Min Cho1
Estimated H-index: 1
(UOU: University of Ulsan),
Junyeop Lee4
Estimated H-index: 4
(Yeungnam University)
+ 10 AuthorsHyun Jung Lee3
Estimated H-index: 3
Abstract This study aimed to determine the safety and tolerability of the subretinal injection of hESC-derived RPE cells at higher doses than the established clinical dose (5 × 10 4 cells/150 μL) by using minipigs. The hESC-derived RPE cells (60 or 120 × 10 4 cells/150 μL) were injected in subretinal region, and minipigs were sacrificed at Weeks 4, 8, and 12 post-surgery. Time-course examination was performed by using fundus photography, optical coherence tomography (OCT), histopathology, and fl...
D. S. Lee2
Estimated H-index: 2
(Seoul National University Hospital),
Minseok Suh6
Estimated H-index: 6
(SNU: Seoul National University)
+ -3 AuthorsDo Won Hwang21
Estimated H-index: 21
(Seoul National University Hospital)
Systemic delivery of exosomes meets hurdles which had not been elucidated using live molecular imaging for their biodistribution. Production and uptake of endogenous exosomes are expected to be nonspecific and specific, respectively, where external stimuli of production of exosomes and their quantitative degree of productions are not understood. Despite this lack of understanding of basic physiology of in vivo behavior of exosomes including their possible paracrine or endocrine actions, many eng...
Published on Apr 19, 2019in Stem Cells Translational Medicine 5.96
Brittni Scruggs (UI: University of Iowa), Chunhua Jiao3
Estimated H-index: 3
(UI: University of Iowa)
+ 8 AuthorsBudd A. Tucker31
Estimated H-index: 31
(UI: University of Iowa)