Evaluation of sequential Bayesian‐based method development procedures for chromatographic problems involving one, two, and three analytes

In this work, various sequential Bayesian‐based method development procedures associated with a search of isocratic chromatographic conditions ensuring baseline separation of one, two, and three analytes within the pre‐specified retention time window were evaluated. The accuracy and total analysis time of tested procedures were experimentally and theoretically verified and compared with the usual approaches utilizing one or two preliminary...