Regression models with asymmetric data for estimating thyroglobulin levels one year after the ablation of thyroid cancer

A key biomarker in the study of differentiated thyroid cancer is thyroglobulin. Measurements of the levels of this protein in the blood are determined using laboratory instruments that cannot detect very small concentrations below a threshold, generating left-censored measurements. In the presence of censoring, ordinary least-squares regression models generate biased parameter estimates; therefore, it is necessary to resort to more complex...