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Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease

Published on Apr 1, 2018in European Journal of Applied Physiology3.06
· DOI :10.1007/s00421-018-3818-y
Jack A. Sargeant2
Estimated H-index: 2
(Lboro: Loughborough University),
Stephen Bawden3
Estimated H-index: 3
(University of Nottingham)
+ 9 AuthorsJames A. King15
Estimated H-index: 15
(Lboro: Loughborough University)
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Abstract
Purpose This study examined the feasibility of sprint interval exercise training (SIT) for men with non-alcoholic fatty liver disease (NAFLD) and its effects on intrahepatic triglyceride (IHTG), insulin sensitivity (hepatic and peripheral), visceral (VAT) and subcutaneous adipose tissue (ScAT).
  • References (55)
  • Citations (2)
Cite
References55
Newest
Published on Dec 1, 2017in Scientific Reports4.01
Hacer Ezgi Karakas1
Estimated H-index: 1
(Sabancı University),
Junyoung Kim12
Estimated H-index: 12
(UNIST: Ulsan National Institute of Science and Technology)
+ 4 AuthorsYoon-Kyoung Cho28
Estimated H-index: 28
(UNIST: Ulsan National Institute of Science and Technology)
Autophagy is a cellular homeostatic mechanism where proteins and organelles are digested and recycled to provide an alternative source of building blocks and energy to cells. The role of autophagy in cancer microenvironment is still poorly understood. Here, we present a microfluidic system allowing monitoring of the crosstalk between single cells. We used this system to study how tumor cells induced autophagy in the stromal niche. Firstly, we could confirm that transforming growth factor β1 (TGF...
Published on Dec 1, 2017in Scientific Reports4.01
Michiru Nishita25
Estimated H-index: 25
(Kobe University),
Seung-Yeol Park4
Estimated H-index: 4
(Brigham and Women's Hospital)
+ 9 AuthorsGregory J. Pazour56
Estimated H-index: 56
(UMMS: University of Massachusetts Medical School)
Signaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for tumor invasion. Here, we identify intraflagellar transport 20 (IFT20) as a new target of this signaling in tumors that lack primary cilia, and find that IFT20 mediates the ability of Ror2 signaling to induce the invasiveness of these tumors. We also find that IFT20 regulates the nucleation of Golgi-derived microtubules by affecting the GM130-AKAP450 complex, which promotes Golgi ribbon formation in achieving p...
Published on Apr 1, 2017in Hepatology14.97
Fernando Bril15
Estimated H-index: 15
(UF: University of Florida),
Diana Barb5
Estimated H-index: 5
(UF: University of Florida)
+ 7 AuthorsKenneth Cusi47
Estimated H-index: 47
The cut-off point of intrahepatic triglyceride (IHTG) content to define nonalcoholic fatty liver disease (NAFLD) by proton magnetic resonance spectroscopy (1H-MRS) was established based on the 95th percentile in a group of healthy individuals (i.e., ≥5.56%). Whether this threshold correlates with metabolic and histological changes and whether a further accumulation of IHTG is associated with worsening of these parameters has not been properly assessed in a large cohort of patients. In this cross...
Published on Mar 1, 2017in Nature Reviews Endocrinology24.65
Lykke Sylow17
Estimated H-index: 17
,
Maximilian Kleinert17
Estimated H-index: 17
+ 1 AuthorsThomas E. Jensen28
Estimated H-index: 28
In this Review, Sylow and colleagues discuss the molecular mechanisms and signalling pathways that regulate glucose uptake from the blood into the muscle during exercise, and the roles of both known and candidate molecules in the process.
Published on Mar 1, 2017in Scientific Reports4.01
Sechang Oh8
Estimated H-index: 8
,
Rina So12
Estimated H-index: 12
+ 7 AuthorsJunichi Shoda34
Estimated H-index: 34
High-Intensity Aerobic Exercise Improves Both Hepatic Fat Content and Stiffness in Sedentary Obese Men with Nonalcoholic Fatty Liver Disease
Published on Jan 1, 2017in Clinical Gastroenterology and Hepatology7.96
David Houghton8
Estimated H-index: 8
(Newcastle University),
Christian Thoma13
Estimated H-index: 13
(Newcastle University)
+ 10 AuthorsChristopher P. Day82
Estimated H-index: 82
(Newcastle University)
Background & Aims Pharmacologic treatments for nonalcoholic steatohepatitis (NASH) are limited. Lifestyle interventions are believed to be effective in reducing features of NASH, although the effect of regular exercise, independent of dietary change, is unclear. We performed a randomized controlled trial to study the effect of exercise on hepatic triglyceride content (HTGC) and biomarkers of fibrosis in patients with NASH. Methods Twenty-four patients (mean age, 52 ± 14 y; body mass index, 33 ± ...
Published on Jan 1, 2017in Digestive Diseases2.91
Stephen Bawden3
Estimated H-index: 3
,
Robert A. Scott3
Estimated H-index: 3
,
Guruprasad P. Aithal39
Estimated H-index: 39
Background: In the past decades, a number of non-invasive methods have emerged for detecting and estimating liver fibrosis; these include both serum-based panels and imaging-based technology. Some of these methods are now being incorporated in clinical practice. However, the limitations of the current techniques include lack of organ specificity, sampling errors and limited ability to reflect the efficacy of interventions. Key Messages: Novel magnetic resonance (MR)-based techniques provide an o...
Published on Dec 1, 2016in International Journal of Obesity4.51
Christopher J. A. Pugh14
Estimated H-index: 14
(Cardiff Metropolitan University),
Victoria S. Sprung13
Estimated H-index: 13
(University of Liverpool)
+ 8 AuthorsGraham J. Kemp51
Estimated H-index: 51
(University of Liverpool)
Exercise-induced improvements in liver fat and endothelial function are not sustained 12 months following cessation of exercise supervision in nonalcoholic fatty liver disease
Published on Oct 1, 2016in Diabetologia7.11
Bram Brouwers6
Estimated H-index: 6
(UM: Maastricht University),
Matthijs K. C. Hesselink52
Estimated H-index: 52
(UM: Maastricht University)
+ 1 AuthorsVera B. Schrauwen-Hinderling26
Estimated H-index: 26
(UM: Maastricht University)
Non-alcoholic fatty liver (NAFL) is the most common liver disorder in western society. Various factors may play a role in determining hepatic fat content, such as delivery of lipids to the liver, de novo lipogenesis, hepatic lipid oxidation, secretion of intrahepatic lipids to the circulation or a combination of these. If delivery of lipids to the liver outweighs the sum of hepatic lipid oxidation and secretion, the intrahepatic lipid (IHL) content starts to increase and NAFL may develop. NAFL i...
Published on Aug 1, 2016in JAMA Internal Medicine20.77
Hui-Jie Zhang3
Estimated H-index: 3
(Tulane University),
Jiang He99
Estimated H-index: 99
(Tulane University)
+ 12 AuthorsQian Sun4
Estimated H-index: 4
(Ha Tai: Xiamen University)
Importance Nonalcoholic fatty liver disease (NAFLD) is a prevalent risk factor for chronic liver disease and cardiovascular disease. Objective To compare the effects of moderate and vigorous exercise on intrahepatic triglyceride content and metabolic risk factors among patients with NAFLD. Design, Setting, and Participants In this randomized clinical trial, participants with central obesity and NAFLD were recruited from community-based screening in Xiamen, China, from December 1, 2011, through D...
Cited By2
Newest
Published on 2019in Medicines
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is associated with an increased risk of type 2 diabetes, cardiovascular disease, cirrhosis, and liver cancer. Exercise therapy is the most effective treatment for patients with NAFLD. High-intensity interval training (HIIT) is attracting attention as a time-efficient and an effective exercise modality for treating patients with NAFLD. Previous studies have shown that HIIT can reduce fat mass, visceral adipose ...
Haitham Abdulla3
Estimated H-index: 3
(University of Nottingham),
Joseph J. Bass3
Estimated H-index: 3
(University of Nottingham)
+ 7 AuthorsPhilip J. Atherton42
Estimated H-index: 42
(University of Nottingham)
Published on Dec 1, 2018in Trials1.98
Katherine González-Ruíz9
Estimated H-index: 9
(Del Rosario University),
Jorge Enrique Correa Bautista11
Estimated H-index: 11
(Del Rosario University)
+ 12 AuthorsEmilio González Jiménez12
Estimated H-index: 12
(UGR: University of Granada)
Background A considerable proportion of contemporary youth have a high risk of obesity-related disorders such as cardiovascular disease, metabolic syndrome, or non-alcoholic fatty liver disease (NAFLD). Although there is consistent evidence for the positive effects of physical activity on several health aspects, most adolescents in Colombia are sedentary. It is, therefore, important to implement strategies that generate changes in lifestyle. The HEPAFIT study aims to examine whether a 6-month ex...
Published on Oct 1, 2018in Obesity Reviews8.19
Jack A. Sargeant2
Estimated H-index: 2
(NIHR: National Institute for Health Research),
Laura J. Gray60
Estimated H-index: 60
(University of Leicester)
+ 5 AuthorsJames A. King15
Estimated H-index: 15
(NIHR: National Institute for Health Research)
This systematic review and meta-analysis determined the impact of structured exercise training, and the influence of associated weight loss, on intrahepatic triglyceride (IHTG) in individuals with non-alcoholic fatty liver disease (NAFLD). It also examined its effect on hepatic insulin sensitivity in individuals with or at increased risk of NAFLD. Analyses were restricted to studies using magnetic resonance spectroscopy or liver biopsy for the measurement of IHTG and isotope-labelled glucose tra...