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Atherosclerosis is a vascular stem cell disease caused by insulin
Abstract
The present article proposes the hypothesis that when multipotent vascular stem cells are exposed to excessive insulin in a rhythmic pattern of sharply rising and falling concentrations, their differentiation is misdirected toward adipogenic and osteogenic cell lineages. This results in plaque-like accumulation of adipocytes with fat and cholesterol deposition from adipocyte debris, and osteogenic (progenitor) cells with a calcified matrix in...
Paper Details
Title
Atherosclerosis is a vascular stem cell disease caused by insulin
Published Date
Jul 1, 2018
Journal
Volume
116
Pages
22 - 27
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History