Defining a Novel Mechanism Mediating the Rate of Heart Failure Progression

Heart failure accounts for 1 of every 4 deaths in the United States every year. Heart failure is a multifaceted disease involving numerous complex axes of the heart. Efforts over the last several decades have sought to define pathogenic mechanisms leading to a decline in heart function. However, to date many disease pathways remain uncharacterized. Here we report a novel axis for the progression of heart failure linked to both structural and...