Substance P ameliorates tumor necrosis factor-alpha-induced endothelial cell dysfunction by regulating eNOS expression in vitro
Abstract
Objective The aim of this study was to explore the beneficial effects of SP on NO production and inflammation-induced vascular endothelium cell death. Methods To mimic the inflammatory environment, TNF-α was treated with HUVECs, and SP was added prior to TNF-α to determine its protective effect. WST-1 assay was performed to detect cell viability. NO level in conditioned medium was measured by Griess Reagent System. The protein level of cleaved...
Paper Details
Title
Substance P ameliorates tumor necrosis factor-alpha-induced endothelial cell dysfunction by regulating eNOS expression in vitro
Published Date
Apr 1, 2018
Journal
Volume
25
Issue
3
Pages
e12443 - e12443
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