TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
Abstract
Mutations in triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to increased Alzheimer’s disease (AD) risk. Neurobiological functions of TREM2 and its pathophysiological ligands remain elusive. Here we found that TREM2 directly binds to β-amyloid (Aβ) oligomers with nanomolar affinity, whereas AD-associated TREM2 mutations reduce Aβ binding. TREM2 deficiency impairs Aβ degradation in primary microglial culture and mouse...
Paper Details
Title
TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
Published Date
Mar 1, 2018
Journal
Volume
97
Issue
5
Pages
1023 - 1031.e7
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