Metabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease

Volume: 46, Issue: 4, Pages: 1565 - 1583
Published: Feb 28, 2018
Abstract
Modified uridine containing taurine, 5-taurinomethyluridine (τm5U), is found at the anticodon first position of mitochondrial (mt-)transfer RNAs (tRNAs). Previously, we reported that τm5U is absent in mt-tRNAs with pathogenic mutations associated with mitochondrial diseases. However, biogenesis and physiological role of τm5U remained elusive. Here, we elucidated τm5U biogenesis by confirming that 5,10-methylene-tetrahydrofolate and taurine are...
Paper Details
Title
Metabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease
Published Date
Feb 28, 2018
Volume
46
Issue
4
Pages
1565 - 1583
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