IGF1R signaling drives antiestrogen resistance through PAK2/PIX activation in luminal breast cancer
Abstract
Antiestrogen resistance in estrogen receptor positive (ER+) breast cancer is associated with increased expression and activity of insulin-like growth factor 1 receptor (IGF1R). Here, a kinome siRNA screen has identified 10 regulators of IGF1R-mediated antiestrogen with clinical significance. These include the tamoxifen resistance suppressors BMPR1B, CDK10, CDK5, EIF2AK1, and MAP2K5, and the tamoxifen resistance inducers CHEK1, PAK2, RPS6KC1,...
Paper Details
Title
IGF1R signaling drives antiestrogen resistance through PAK2/PIX activation in luminal breast cancer
Published Date
Jan 22, 2018
Journal
Volume
37
Issue
14
Pages
1869 - 1884
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Notes
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