TRPC1/3/6 inhibition attenuates the TGF‐β1‐induced epithelial–mesenchymal transition in gastric cancer via the Ras/Raf1/ERK signaling pathway

Gastric cancer (GC) is one of the most common malignancies worldwide. TGF‐β1 induces the epithelial–mesenchymal transition (EMT) in GC, mainly through Smad‐dependent pathways. Nevertheless, few studies have focused on the activation of non‐canonical transduction pathways. TRPC, Ca 2+ entry channels, are ubiquitously expressed in various cell types and are involved in many cellular functions. However, their roles in GC are not well elucidated....