SETD7 Drives Cardiac Lineage Commitment through Stage-Specific Transcriptional Activation
Abstract
Cardiac development requires coordinated and large-scale rearrangements of the epigenome. The roles and precise mechanisms through which specific epigenetic modifying enzymes control cardiac lineage specification, however, remain unclear. Here we show that the H3K4 methyltransferase SETD7 controls cardiac differentiation by reading H3K36 marks independently of its enzymatic activity. Through chromatin immunoprecipitation sequencing (ChIP-seq),...
Paper Details
Title
SETD7 Drives Cardiac Lineage Commitment through Stage-Specific Transcriptional Activation
Published Date
Mar 1, 2018
Journal
Volume
22
Issue
3
Pages
428 - 444.e5
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