Protein homology model refinement by large-scale energy optimization

Volume: 115, Issue: 12, Pages: 3054 - 3059
Published: Mar 5, 2018
Abstract
Significance Protein structure refinement by direct global energy optimization has been a longstanding challenge in computational structural biology due to limitations in both energy function accuracy and conformational sampling. This manuscript demonstrates that with recent advances in both areas, refinement can significantly improve protein comparative models based on structures of distant...
Paper Details
Title
Protein homology model refinement by large-scale energy optimization
Published Date
Mar 5, 2018
Volume
115
Issue
12
Pages
3054 - 3059
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