Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality
Abstract
High-grade glioma (HGG) is highly angiogenic, but antiangiogenic therapy has transient clinical benefit in only a fraction of patients. Vascular regulators of these heterogeneous responses remain undetermined. We found up-regulation of Sox7 and down-regulation of Sox17 in tumor endothelial cells (tECs) in mouse HGG. Sox7 deletion suppressed VEGFR2 expression, vascular abnormality, hypoxia-driven invasion, regulatory T cell infiltration, and...
Paper Details
Title
Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality
Published Date
Feb 14, 2018
Volume
215
Issue
3
Pages
963 - 983
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