Phospholipase A<sub>2</sub> of Microbiota as Pathogenetic Determinant to Induce Inflammatory States in Ulcerative Colitis: Therapeutic Implications of Phospholipase A<sub>2</sub> Inhibitors

Volume: 2, Issue: 3, Pages: 180 - 187
Published: Jan 1, 2017
Abstract
<b><i>Background:</i></b> Attack by commensal microbiota is one component of induction of inflammatory episodes in ulcerative colitis (UC). In UC, the mucus layer is intrinsically devoid of phosphatidylcholine (PC) resulting in low hydrophobicity which facilitates bacterial invasion. Colonic ectophospholipase-carrying bacterial strains are likely candidates to further thinning the PC mucus barrier and to precipitate...
Paper Details
Title
Phospholipase A&lt;sub&gt;2&lt;/sub&gt; of Microbiota as Pathogenetic Determinant to Induce Inflammatory States in Ulcerative Colitis: Therapeutic Implications of Phospholipase A&lt;sub&gt;2&lt;/sub&gt; Inhibitors
Published Date
Jan 1, 2017
Volume
2
Issue
3
Pages
180 - 187
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