Opposite effect of polyamines on In vitro gene expression: Enhancement at low concentrations but inhibition at high concentrations

Background Polyamines have various biological functions including marked effects on the structure and function of genomic DNA molecules. Changes in the higher-order structure of DNA caused by polyamines are expected to be closely related to genetic activity. To clarify this issue, we examined the relationship between gene expression and the higher-order structure of DNA under different polyamine concentrations. Principal findings We studied the...