Pharmacogenomics of Hypertension and Preeclampsia: Focus on Gene–Gene Interactions

Hypertension is a leading cause of cardiovascular mortality, but only about half of patients on antihypertensive therapy achieve blood pressure control. Preeclampsia is defined as pregnancy-induced hypertension and proteinuria, and is associated with increased maternal and perinatal mortality and morbidity. Similarly, a large number of patients with preeclampsia are nonresponsive to antihypertensive therapy. Pharmacogenomics may help to guide...