Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer
Abstract
Sterol regulatory element-binding proteins (SREBPs) belong to a family of transcription factors that regulate the expression of genes required for the synthesis of fatty acids and cholesterol. Three SREBP isoforms, SREBP1a, SREBP1c, and SREBP2, have been identified in mammalian cells. SREBP1a and SREBP1c are derived from a single gene through the use of alternative transcription start sites. Here we investigated the role of SREBP-mediated...
Paper Details
Title
Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer
Published Date
Feb 15, 2018
Journal
Volume
9
Issue
3
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