doi.org/10.1016/j.colsurfb.2018.02.016
Original paper

The effect of the molecular weight of hyaluronic acid on the physicochemical characterization of hyaluronic acid-curcumin conjugates and in vitro evaluation in glioma cells

..., Yanyu Xiao
26
Colloids and Surfaces B Biointerfaces5.40
Volume: 165, Pages: 45 - 55
Published: May 1, 2018
Abstract
In this study, a redox-sensitive glioma-targeting micelle system was designed to deliver curcumin (CUR) by conjugating it to hyaluronic acid (HA-s-s-CUR, HSC) via disulfide linkage. The effect of the molecular weight of HA on the physicochemical characteristics of HSC conjugates and their in vitro effects in glioma cells were also explored. These conjugates formed nano-scale micelles (209-926 nm) independently in aqueous solution. The micelles...
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Paper Details
Title
The effect of the molecular weight of hyaluronic acid on the physicochemical characterization of hyaluronic acid-curcumin conjugates and in vitro evaluation in glioma cells
DOI
doi.org/10.1016/j.colsurfb.2018.02.016
Published Date
May 1, 2018
Journal
Colloids and Surfaces B Biointerfaces
Volume
165
Pages
45 - 55
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