A potent complement factor C3–specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement
Abstract
The complement system is a complex, carefully regulated proteolytic cascade for which suppression of aberrant activation is of increasing clinical relevance, and inhibition of the complement alternative pathway is a subject of intense research. Here, we describe the nanobody hC3Nb1 that binds to multiple functional states of C3 with subnanomolar affinity. The nanobody causes a complete shutdown of alternative pathway activity in human and murine...
Paper Details
Title
A potent complement factor C3–specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement
Published Date
Apr 1, 2018
Volume
293
Issue
17
Pages
6269 - 6281
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