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Association between systemic leptin and neurotensin concentration in adult individuals with and without type 2 diabetes mellitus

Published on Oct 1, 2018in Journal of Endocrinological Investigation
路 DOI :10.1007/s40618-018-0845-9
Ilaria Barchetta12
Estimated H-index: 12
(Sapienza University of Rome),
G. Ciccarelli1
Estimated H-index: 1
(Sapienza University of Rome)
+ 4 AuthorsMaria Gisella Cavallo23
Estimated H-index: 23
(Sapienza University of Rome)
Abstract
Purpose Leptin is an adipokine which regulates appetite and energy balance through a mechanism partially mediated by neurotensin (NT) in central nervous system. Besides acting as a neurotransmitter, NT is expressed in human intestine where it promotes fat absorption and its circulating levels associate with obesity, type 2 diabetes mellitus (T2DM) and cardiovascular disease. Whether a relation exists between circulating leptin and NT levels has not been investigated yet. The aim of this study was to test the hypothesis of an association between plasma leptin and NT concentration in adults with or without T2DM.
  • References (22)
  • Citations (5)
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References22
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#1Jing-Jing LiuH-Index: 1
#2Nicholas T. Bello (RU: Rutgers University)H-Index: 19
Last. Zhiping P. Pang (RU: Rutgers University)H-Index: 31
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Synaptic transmission controls brain activity and behaviors, including food intake. Leptin, an adipocyte-derived hormone, acts on neurons located in the lateral hypothalamic area (LHA) to maintain energy homeostasis and regulate food intake behavior. The specific synaptic mechanisms, cell types, and neural projections mediating this effect remain unclear. In male mice, using pathway-specific retrograde tracing, whole-cell patch-clamp recordings and post hoc cell type identification, we found tha...
15 CitationsSource
#1Craig Beall (University of Exeter)H-Index: 7
#2Lydia Hanna (University of Exeter)H-Index: 1
Last. Kate L. J. Ellacott (University of Exeter)H-Index: 24
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Our understanding of adipose tissue as an endocrine organ has been transformed over the last 20 years. During this time, a number of adipocyte-derived factors or adipokines have been identified. This article will review evidence for how adipokines acting via the central nervous system (CNS) regulate normal physiology and disease pathology. The reported CNS-mediated effects of adipokines are varied and include the regulation of energy homeostasis, autonomic nervous system activity, the reproducti...
5 CitationsSource
#1Juliette A. Brown (MSU: Michigan State University)H-Index: 5
#2Raluca Bugescu (MSU: Michigan State University)H-Index: 5
Last. Gina M. Leinninger (MSU: Michigan State University)H-Index: 24
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Abstract The hormones ghrelin and leptin act via the lateral hypothalamic area (LHA) to modify energy balance but the underlying neural mechanisms remain unclear. We investigated how leptin and ghrelin engage LHA neurons to modify energy balance behaviors and whether there is any cross-talk between leptin and ghrelin-responsive circuits. We demonstrate that ghrelin activates LHA neurons expressing Hypocretin/Orexin (OX) to increase food intake. Leptin mediates anorectic actions via separate neur...
20 CitationsSource
Objective鈥 Neurotensin is a peptide whose receptor (sortilin receptor 1) is linked to cardiovascular disease (CVD) development. We hypothesized concentrations of proneurotensin (stable profragment of neurotensin) would predict incident cardiovascular events in community-based subjects. Approach and Results鈥 Blood samples from 3439 participants in the Framingham Heart Study (FHS) Offspring cohort (mean age 59.2 years, 47.1% male) were tested for proneurotensin. Primary outcome of interest was inc...
14 CitationsSource
#1Jing Li (UK: University of Kentucky)H-Index: 21
#2Jun Song (UK: University of Kentucky)H-Index: 10
Last. B. Mark Evers (UK: University of Kentucky)H-Index: 66
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Neurotensin, a peptide expressed in the enteroendocrine cells of the small intestine that is released upon fat ingestion, is shown to increase fatty acid absorption, with neurotensin-deficient mice being protected from obesity induced by a high-fat diet.
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#2Cecilia F. Ratner (Novo Nordisk Foundation)H-Index: 1
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The 2 gut hormones glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) are well known to be coexpressed, costored, and released together to coact in the control of key metabolic target organs. However, recently, it became clear that several other gut hormones can be coexpressed in the intestinal-specific lineage of enteroendocrine cells. Here, we focus on the anatomical and functional consequences of the coexpression of neurotensin with GLP-1 and PYY in the distal small intestine. Fluorescence-...
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#1Heike M眉nzberg (Pennington Biomedical Research Center)H-Index: 27
#2Christopher D. Morrison (Pennington Biomedical Research Center)H-Index: 33
The cloning of leptin in 1994 was an important milestone in obesity research. In those days obesity was stigmatized as a condition caused by lack of character and self-control. Mutations in either leptin or its receptor were the first single gene mutations found to cause morbid obesity, and it is now appreciated that obesity is caused by a dysregulation of central neuronal circuits. From the first discovery of the leptin deficient obese mouse (ob/ob), to the cloning of leptin (ob aka lep) and le...
118 CitationsSource
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#2Jaione Barrenetxe (University of Navarra)H-Index: 12
Last. Jos茅 Alfredo Mart铆nez (University of Navarra)H-Index: 83
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Abstract Obesity is a chronic disease that represents one of the most serious global health burdens associated to an excess of body fat resulting from an imbalance between energy intake and expenditure, which is regulated by environmental and genetic interactions. The adipose-derived hormone leptin acts via a specific receptor in the brain to regulate energy balance and body weight, although this protein can also elicit a myriad of actions in peripheral tissues. Obese individuals, rather than be...
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Abstract Background and Aims Neurotensin (NT) is a gut hormone with broad effects on the cardiovascular system. Recent data suggested that circulating pro-neurotensin (pro-NT) ---the stable precursor fragment of NT---could independently predict cardiovascular artery disease (CAD) development. However, serum pro-NT levels in premature cardiovascular artery disease (PCAD) patients are still unknown. This study aims to detect serum pro-NT levels in PCAD patients and investigate its relationship wit...
Source
Abstract Nowadays the adipose tissue is recognized as one of the most critical endocrine organs releasing many adipokines that regulate metabolism, inflammation and body homeostasis. There are several described adipokines, including the renin-angiotensin system (RAS) components that are especially activated in some diseases with increased production of angiotensin II and several pro-inflammatory hormones. On the other hand, RAS also expresses angiotensin-(1鈥7), which is now recognized as the mai...
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#1Ilaria Barchetta (Sapienza University of Rome)H-Index: 12
#2Flavia Agata Cimini (Sapienza University of Rome)H-Index: 7
Last. Maria Gisella Cavallo (Sapienza University of Rome)H-Index: 23
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Abstract Background and aims Pro-Neurotensin (NT), a stable surrogate parameter of NT, has recently been introduced as a peptide predicting the development of obesity, diabetes mellitus, cardiovascular diseases, and cardiovascular mortality. However, regulation of Pro-NT in gestational diabetes mellitus (GDM) remains uninvestigated. Methods and results Pro-NT was quantified in 74 women with GDM, 74 healthy, gestational age-matched, pregnant controls, as well as in a second cohort comprising of 7...
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#1Silvano Paternoster (Curtin University)H-Index: 3
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An aging world population exposed to a sedentary life style is currently plagued by chronic metabolic diseases, such as type-2 diabetes, that are spreading worldwide at an unprecedented rate. One of the most promising pharmacological approaches for the management of type 2 diabetes takes advantage of the peptide hormone glucagon-like peptide-1 (GLP-1) under the form of protease resistant mimetics, and DPP-IV inhibitors. Despite the improved quality of life, long-term treatments with these new cl...
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#2Flavia Agata Cimini (Sapienza University of Rome)H-Index: 7
Last. Maria Gisella Cavallo (Sapienza University of Rome)H-Index: 23
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