Association between systemic leptin and neurotensin concentration in adult individuals with and without type 2 diabetes mellitus

Published on Oct 1, 2018in Journal of Endocrinological Investigation
路 DOI :10.1007/s40618-018-0845-9
Ilaria Barchetta12
Estimated H-index: 12
(Sapienza University of Rome),
G. Ciccarelli1
Estimated H-index: 1
(Sapienza University of Rome)
+ 4 AuthorsMaria Gisella Cavallo23
Estimated H-index: 23
(Sapienza University of Rome)
Purpose Leptin is an adipokine which regulates appetite and energy balance through a mechanism partially mediated by neurotensin (NT) in central nervous system. Besides acting as a neurotransmitter, NT is expressed in human intestine where it promotes fat absorption and its circulating levels associate with obesity, type 2 diabetes mellitus (T2DM) and cardiovascular disease. Whether a relation exists between circulating leptin and NT levels has not been investigated yet. The aim of this study was to test the hypothesis of an association between plasma leptin and NT concentration in adults with or without T2DM.
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