Voglibose-mediated alterations in neurometabolomic profiles in the hypothalamus of high-fat diet-fed mice
Abstract
The alpha-glucosidase inhibitor voglibose (VO) was recently reported to have a protective effect against weight gain as well as affect various metabolic changes related to food intake and gut-brain signaling. We hypothesized that VO prevents weight gain by altering neurometabolome profiles in the hypothalamus to reduce food intake. To test this hypothesis, we assessed metabolite profiles in the hypothalamus of standard diet- or high-fat (HF)...
Paper Details
Title
Voglibose-mediated alterations in neurometabolomic profiles in the hypothalamus of high-fat diet-fed mice
Published Date
Mar 1, 2018
Journal
Volume
22
Issue
11
Pages
760 - 767
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