Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function
Abstract
Serine palmitoyltransferase (SPT) is the rate-limiting enzyme for sphingolipid biosynthesis. SPT has two major subunits, SPTLC1 and SPTLC2. We previously found that liver Sptlc2 deficiency in early life impairs the development of adherens junctions. Here, we investigated the role of Sptlc2 deficiency in intestine. We treated Sptlc2-Flox/villin-Cre-ERT2 mice with tamoxifen (days 1, 2, and 3) to ablate Sptlc2 specifically in the intestine. At day...
Paper Details
Title
Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function
Published Date
Feb 7, 2018
Journal
Volume
9
Issue
2
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